5,6-Dihydro-2,3,9,10-tetramethoxy-13-methyldibenzo[a,g]quinolizinium
Dehydrocorydaline
CAS: 30045-16-0
Molecular Formula: C22H24NO4
5,6-Dihydro-2,3,9,10-tetramethoxy-13-methyldibenzo[a,g]quinolizinium - Names and Identifiers
5,6-Dihydro-2,3,9,10-tetramethoxy-13-methyldibenzo[a,g]quinolizinium - Physico-chemical Properties
| Molecular Formula | C22H24NO4 |
| Molar Mass | 366.436 |
| Melting Point | 170-173℃ |
| Solubility | Soluble in acidic solution, insoluble in petroleum ether and other solvents. |
| Appearance | Yellow powder |
| Storage Condition | Inert atmosphere,Room Temperature |
| MDL | MFCD00887635 |
| Physical and Chemical Properties | Yellow needle crystal powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Corydalis, Yuanhu. |
| In vitro study | Dehydrocorydaline (0-200 μM) treatment significantly inhibits the growth of MCF-7 cells in a dose-dependent manner. The cell viability is decreased by approximate 40% after 24 h of 200 μM Dehydrocorydaline. Dehydrocorydaline (0-200 μM)dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression. Dehydrocorydaline (0-200 μM)induces activation of caspase-7,-8 and the cleavage of PARP without affecting caspase-9. |
| In vivo study | Dehydrocorydaline manifests a low acute toxicity with an LD 50 of about 277.5±19.0 mg/kg body weight in mice following oral administration and 21.1±1.4 mg/kg for intraperitoneal injection. |
5,6-Dihydro-2,3,9,10-tetramethoxy-13-methyldibenzo[a,g]quinolizinium - Reference
| Reference Show more | 1. LIU Zhenzhen, White Bridge, Xu Hao. Effects of different primary processing methods on contents of five alkaloids in Corydalis yanhusuo [J]. Modern Agricultural Science and Technology 2019 000(022):173-176. 2. Lvhua Wang, Yumei Zhao, Yanan Zhang, tinting Zhang, Jeroen Kool, government W. Somsen, Qiqin Wang, Zheng Jin Jiang, Online screening of ketylcholinesterase inhibitors in natural products using monolith-based immobilizary capital vaccines combined wi 3. Zhang, Y., wang, Z., xu, J. et al. Optimization of the extraction and purification of Corydalis yanhusuo W.T. Wang based on the Q-marker uniform design method. BMC Chemistry 14, 9 (2020). https://doi.org/10.1186/s13065-020-00666-6 4. [IF=4.759] Lvhuan Wang et al."Online screening of acetylcholinesterase inhibitors in natural products using monolith-based immobilized capillary enzyme reactors combined with liquid chromatography-mass spectrometry."J Chromatogr A. 2018 Aug;1563:135 5. [IF=4.759] Yanyan Zhang et al."Rapid screening and identification of monoamine oxidase-A inhibitors from Corydalis Rhizome using enzyme-immobilized magnetic beads based method."J Chromatogr A. 2019 May;1592:1 |
5,6-Dihydro-2,3,9,10-tetramethoxy-13-methyldibenzo[a,g]quinolizinium - Reference Information
| biological activity | Dehydrocorydaline (13-methylpalmatine) is an alkaloid isolated from Corydalis husuo, a traditional Chinese medicine. Dehydrocorydaline regulates Bax,Bcl-2 protein expression; Activates caspase-7,caspase-8 and inactivates PARP. Dehydrocorydaline can enhance the activation of p38 MAPK, with anti-inflammatory, anti-cancer and other effects.. Dehydrocorydaline has a powerful antimalarial effect and low cytotoxicity (cell viability> 90%), P. falciparum 3D7 strain (IC50=38 nM). |
| Use | dehydrocorydaline has analgesic and sedative effects. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: with bactericidal, anti-inflammatory effect. |
Last Update：2024-04-09 20:52:54
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Product Name: Dehydrocorydaline Visit Supplier Webpage Request for quotationCAS: 30045-16-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Dehydrocorydaline Visit Supplier Webpage Request for quotationCAS: 30045-16-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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